Disordered functional connectivity in schizophrenia
نویسندگان
چکیده
منابع مشابه
Disordered functional connectivity in schizophrenia.
The first functional neuroimaging studies of schizophrenia, using single photon (SPET) and positron emission tomography (PET), led to the notion of abnormal 'hypofrontality' (Ingvar & Franzen, 1974). Although consistent with data linking schizophrenia with deficits in frontal function, the popularity of'hypofrontality' gradually faded as technically and methodologically more sophisticated studi...
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We explored fronto-temporal connectivity using fMRI of patients and controls generating inner speech. Method The subjects were eight schizophrenic patients in remission recruited from the wards and clinics of the Maudsley Hospital, and 8 controls matched for age, sex and IQ. Diagnosis was made by clinical interview and case-note review, using DSM IV criteria. All subjects were trained to overtl...
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BACKGROUND Schizophrenia is characterized by a lack of integration between thought, emotion, and behavior. A disruption in the connectivity between brain processes may underlie this schism. Functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) were used to evaluate functional and anatomical brain connectivity in schizophrenia. METHODS In all, 29 chronic schizophrenia...
متن کاملFunctional connectivity density alterations in schizophrenia
BACKGROUND Schizophrenia is characterized by altered resting-state functional connectivity. Most previous studies have focused on changes in connectivity strengths; however, the alterations in connectivity density in schizophrenia remain largely unknown. Here, we aimed to investigate changes in resting-state functional connectivity density (rsFCD) in schizophrenia. METHODS A total of 95 schiz...
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Schizophrenia has often been conceived as a disorder of connectivity between components of large-scale brain networks. We tested this hypothesis by measuring aspects of both functional connectivity and functional network topology derived from resting-state fMRI time series acquired at 72 cerebral regions over 17 min from 15 healthy volunteers (14 male, 1 female) and 12 people diagnosed with sch...
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ژورنال
عنوان ژورنال: Psychological Medicine
سال: 1996
ISSN: 0033-2917,1469-8978
DOI: 10.1017/s0033291700037673